中华医学杂志（英文版）2002，Vol.115Issue(3)：375-377,3.
灯盏花对自发性高血压大鼠心室重构的药物干预研究
Ventricular remodeling by Scutellarein treatment in spontaneously hypertensive rats
周建中 1雷寒 1陈运贞 1李法琦 1马长生2
作者信息
- 1. 重庆医科大学附属第一医院心血管内科,重庆,400016
- 2. 北京中日友好医院,北京,100029
- 折叠
摘要
Abstract
Objective To observe reversal of ventricular remodeling by the protein kinase C inhibitor Scutellarein in spontaneously hypertensive rats (SHRs). Methods Twelve SHRs were randomly divided into two groups. Scutellarein and saline (10?mg*kg-1*d-1) were given by intraperitoneal injection to two groups of rats separately. Systolic blood pressure (SBP) and ventricular weight index (LVW/BW, RVW/BW) were measured. A polarization microscope and an image analyzer system (IAS) were used to observe changes in cardiovascular structure and to count the content of cardiac muscle interstitial collagen. Results The pathologic changes in the left ventricle in the Scutellarein group rats (SHRD) improved to varying degrees, including hypertrophy of the cardiac muscle and collagen volume fraction. Conclusion Scutellarein can reverse ventricular remodeling, improve myocardial stiffness and protect heart cardiac muscle. 关键词
自发性高血压大鼠/心室重构/灯盏花/胶原Key words
spontaneously/hypertensive rat/ventricular remodeling/Scutellarein/collagen分类
医药卫生引用本文复制引用
周建中,雷寒,陈运贞,李法琦,马长生..灯盏花对自发性高血压大鼠心室重构的药物干预研究[J].中华医学杂志（英文版）,2002,115(3):375-377,3.
