中德临床肿瘤学杂志(英文版)2006，Vol.5Issue(5)：376-378,3.
益康唑诱导HL-60白血病细胞内质网应激反应性细胞凋亡
A preliminary study on the econazole induced endoplasmic reticulum related apoptosis in HL-60 leukemic cells
胡珍娉 1刘文励 1Stuart Berger1
作者信息
摘要
Abstract
Objective: To investigate the anti-leukemic function of econazole (Ec),an azole anti-fungal drug.Methods: We compared efficacy of econazole to induce apoptosis in HL-60 cells with two other known endoplasmic reticulum (ER) stress inducer thapsigargin (Tg) and tunicamycin (Tu).Results: Cells treated with Ec showed typical morphology of apoptosis following24 h incubation,parallel to the morphological changes,the expression of molecular chaperone GRP 78 was up-regulated in all cases and the caspase 12,an ER resident caspase was activated.Conclusion: Ec induced ER stress related apoptosis in HL-60 cells; the underlying mechanisms are protein synthesis inhibition through elF2α phosphorylation and caspase 12 activation.关键词
leukemia/endoplasmic reticulum stress/apoptosisKey words
leukemia/endoplasmic reticulum stress/apoptosis分类
医药卫生引用本文复制引用
胡珍娉,刘文励,Stuart Berger..益康唑诱导HL-60白血病细胞内质网应激反应性细胞凋亡[J].中德临床肿瘤学杂志(英文版),2006,5(5):376-378,3.
