Adenovirus-mediated hypoxia-inducible factor-1 alpha gene transfer induces angiogenesis and neurogenesis following cerebral ischemia in ratsOACSCD
Adenovirus-mediated hypoxia-inducible factor-1 alpha gene transfer induces angiogenesis and neurogenesis following cerebral ischemia in rats
BACKGROUND: Hypoxia-inducible factor-1 (HIF-1) accumulates under conditions of hypoxia. HIF-1α target genes have pleiotropic effects on neurogenesis, neuroprotection and angiogenesis in the brain.OBJECTIVE: To investigate whe…查看全部>>
BACKGROUND: Hypoxia-inducible factor-1 (HIF-1) accumulates under conditions of hypoxia. HIF-1α target genes have pleiotropic effects on neurogenesis, neuroprotection and angiogenesis in the brain.OBJECTIVE: To investigate whether a recombinant adenovirus carrying HIF-1α can increase the expression of HIF-1α in vivo and thus promote angiogenesis and neurogenesis in a rat model of focal cerebral ischemia.DESIGN, TIME AND SETTING: The randomized, controlled exp…查看全部>>
Wanfu Wu;Xiu Chen;Zhen Yu;Changlin Hu;Wenqin Cai
Department of Neurology, the Second Affiliated Hospital, Chongqing Medical University, Chongqing 400016, ChinaDepartment of Neurology, the Second Affiliated Hospital, Chongqing Medical University, Chongqing 400016, ChinaDepartment of Neurology, the Second Affiliated Hospital, Chongqing Medical University, Chongqing 400016, ChinaDepartment of Neurology, the Second Affiliated Hospital, Chongqing Medical University, Chongqing 400016, ChinaDepartment of Neurobiology, Third Military Medical University of Chinese PLA, Chongqing 400038, China
医药卫生
hypoxia-inducible factor-1α rats angiogenesis neurogenesis focal ischemia
hypoxia-inducible factor-1α rats angiogenesis neurogenesis focal ischemia
《中国神经再生研究（英文版）》 2008 (4)
378-383,6
Key Program of Chongqing Municipal Health Bureau, No. 06-01-020
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