中国临床康复2003，Vol.7Issue(28)：3802-3803,2.
c-fos在阿尔茨海默病及血管性痴呆模型大鼠脑中的表达
Brain c-fos gene expression in two rat models of Alzheimer's disease and vascular dementia:a comparative study
摘要
Abstract
AIM:To investigate the characteristics of c-fos expression in the brain of rat Alzheimer's disease(AD) and vascular dementia(VD) models. METHODS:Twenty-one male SD rats which had passed Y-maze test were divided randomly into control group (n=3),AD model group (n=9) and VD model group (n=9).AD models were established by complete severing of the unilateral fimbria hippocampi of the rats, and VD model by Fe3O4 powder injection into the sublingual vein and fixation of a magnet on the skull surface of the rat.At different time points after model establishment as verified by Y-maze test,Fos immunohistochemical staining of the slices of the brain tissue including the hippocampus was performed. RESULTS:The Fos-like immunoactivity (Fos-LI) increased markedly in the cortex and hippocampus of rat AD models, which intensified gradually with the elapse of time.Fos-LI also increased on the second day after VD model was induced, on the day 7, normal condition was resumed, and the Fos-LI was far more intense in the cortex than in the hippocampus. CONCLUSION:c-fos expression varies spatially and temporally between rat AD and VD models.关键词
阿尔茨海默病/痴呆,血管性/基因,fos分类
医药卫生引用本文复制引用
王跃春,王子栋,何斯纯,郑辉,柏志全..c-fos在阿尔茨海默病及血管性痴呆模型大鼠脑中的表达[J].中国临床康复,2003,7(28):3802-3803,2.基金项目
广东省卫生系统"五个一科技兴医工程" (04345)及国务院侨办重点课题科研基金 (939506) （04345）
