中华医学杂志（英文版）2002，Vol.115Issue(3)：381-382,2.
幽门螺杆菌感染患者血清可溶性幽门螺杆菌抗原及其 IgG,IgA型免疫复合物测定
Helicobacter pylori antigen and its IgG, IgA -type specific immunocomplexes in sera from patients with Helicobacter pylori infection
朱永良 1林洁 2李达 3杜勤 1钱可大 1吴勤动 1郑树4
作者信息
- 1. 浙江大学医学院附属第二医院,杭州,310009
- 2. 浙江大学医学院附属邵逸夫医院,杭州,310016
- 3. 上海第一人民医院,上海,200000
- 4. 浙江大学肿瘤研究所,杭州,310016
- 折叠
摘要
Abstract
Objective To explore the characteristics of Helicobacter pylori (H.pylori) antigen in serum and to evaluate its clinical diagnostic value. Methods Enzyme-linked immunosorbant assay (ELISA) was developed to detect the soluble H.pylori antigen (S-Hp) and circulatory specific H.pylori antigen immunocomplexes (Hp-IC) in serum. Results The positive rate of S-Hp was 90.91% from 66 patients with H. pylori infection, which was much greater than 0% found in 28 controls (P<0.001). Moreover, its concentration closely reflected the number of H.pylori in the gastric mucosa layer. We also found that Hp-IC existed bound with IgG and/or IgA in patients with positive S-Hp. However, there is no evidence to show the concentration of S-Hp reduced significantly in followed-up subjects after effective therapy. Conclusions These methods as newly and noninvasive complementary tools can be used for clinical diagnosis of H.pylori infection. In addition, S-Hp and Hp-IC may be of importance in H.pylori pathogenesis.关键词
血清学诊断/可溶性幽门螺杆菌抗原/幽门螺杆菌特异性免疫复合物/酶免疫测定法Key words
serological diagnosis/soluble Helicobacter pylori antigens/specific immunocompound/enzyme immunoassay分类
医药卫生引用本文复制引用
朱永良,林洁,李达,杜勤,钱可大,吴勤动,郑树..幽门螺杆菌感染患者血清可溶性幽门螺杆菌抗原及其 IgG,IgA型免疫复合物测定[J].中华医学杂志（英文版）,2002,115(3):381-382,2.
