中国临床康复2004，Vol.8Issue(2)：382-384,3.
强骨抗萎方对骨细胞代谢及血液流变学的影响
Effects of bone enbancement and anti-atrophy herb compound on osteocyte metabolism and blood rheological property
李勇枝 1石宏志 1范全春 1陶英 1白桂娥 1段渊儒 1谢俊水1
作者信息
- 1. 航天医学工程研究所,北京市,100094
- 折叠
摘要
Abstract
AIM:To investigate the effects of Traditional Chinese Medicine (TCM) herb compound of bone enhancement and anti atrophy recipe on the blood rheological property in cauda hanged rat.METHODS:Rat was hanged by its cauda in 30° for 21 days to imitate weightlessness.The effect of bone enhancement and anti atrophy herb compound on the index of blood sedimentation rate,hematocrit, fibrinogen, blood viscosity as well as erythrocyte deformability and aggregation was observed. RESULTS:The fibrinogen of the cauda hanged rat increased significantly(P< 0.01);blood deoxidizing viscosity and blood viscosity increased significantly(P< 0.01 or P< 0.05);erythrocyte rigid index increased(P< 0.01); the maximum deformability index decreased(P< 0.01); and the maximum aggregation index increased (P< 0.01). Different effects were demonstrated by different doses of this compound. Low dose(10 g/kg) could decrease blood deoxidizing viscosity and blood viscosity under every shearing strain rate (P< 0.01 or P< 0.05) as well as abnormal erythrocyte rigid index and maximum aggregation index (P< 0.01). Medium dose (20 g/kg) could decrease the content of fibrinogen (P< 0.01). And high dose (30 g/kg) could decrease blood deoxidizing viscosity and blood viscosity under high shearing strain rate(P< 0.01 or P< 0.05) as well as erythrocyte rigid index(P< 0.01) but increasing erythrocyte maximum deformability index(P< 0.01). CONCLUSION: The herb compound can modify the blood rheological property in cauda hanged rat; however, there is no obvious dose effect relationship.关键词
中药疗法/失重模拟/大鼠/血液黏度/红细胞变形性/红细胞聚集分类
医药卫生引用本文复制引用
李勇枝,石宏志,范全春,陶英,白桂娥,段渊儒,谢俊水..强骨抗萎方对骨细胞代谢及血液流变学的影响[J].中国临床康复,2004,8(2):382-384,3.
