河北医学2001，Vol.7Issue(5)：385-388,4.
二甲基亚砜和珍黄注射液联合用药对小鼠宫颈癌的抗癌作用
Antitumor effect of combination of dimethl sulphoxide and Zhenhuang injection on cervical carcinoma of mice
罗丽莉 1许锦阶 2徐虹 2徐小虎2
作者信息
- 1. 汕头大学医学院第一附属医院妇产科,
- 2. 汕头大学医学院病理学和病理生理学系,
- 折叠
摘要
Abstract
Objective: To explore the antitumor effect of combination of dimethl sulphoxide (DMSO) and Zhenhuang injection (ZHI) on cervical carcinoma of mice so as to provide scientific dasis for clinical experiments. Methods: The model of ascitic tumor and the model of solid tumor of cervical carcinoma U14 were treated with DMSO(50mg/Kg), ZHI(20mg/Kg) and DMSO with ZHI(DMSO 50mg/Kg, ZHI 20mg/Kg), respectively.The efficacy estimation indices of the test included the life-prolonging rate and the tumor-inhibiting rate.The experiment was repeated two times. Results: The treatment to ascitic tumor, the life-prolonging rates were 21.37%～25.86%, 41.38%～43.59%, and 65.81%～69.83% in DMSO group, ZHI group and in group of combination of DMSO and ZHI, respectively. Through statistic analysis, there was significant difference between the treated groups and control group(P<0.01). There was marked difference in group of combination of DMSO and ZHI, compared with DMSO group or ZHI group(P<0.01). The treatment to solid tumor, the tumor-inhibiting rates were 22.50%～25.83%, 37.50%～41.67%,and 60.83%～68.33% in DMSO group, ZHI group and in combined group, respectively. Through statistical analysis, there was remarkable or very remarkable difference between treated groups and control group(P<0.05 or P<0.01).There was marked difference in the combined group, compared with single treatment group(P<0.01). Conclusions: ZHI had certain antitumor effect on cervical carcinoma U14 of mice. Combination of DMSO and ZHI might produce additive effect.关键词
宫颈癌/二甲基亚砜/珍黄注射液/抗癌作用分类
医药卫生引用本文复制引用
罗丽莉,许锦阶,徐虹,徐小虎..二甲基亚砜和珍黄注射液联合用药对小鼠宫颈癌的抗癌作用[J].河北医学,2001,7(5):385-388,4.
