南京医科大学学报（英文版）2007，Vol.21Issue(6)：386-389,4.
The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics
The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics
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作者信息
- 1. Department of Anesthesiology,the First Affiliated Hospital of Nanjmg Medical University,Nanjing 210029,Jiangsu Province,China;Department of Anesthesiology,the First Affiliated Hospital of Nanjmg Medical University,Nanjing 210029,Jiangsu Province,China;Department of Anesthesiology,the First Affiliated Hospital of Nanjmg Medical University,Nanjing 210029,Jiangsu Province,China;Department of Anesthesiology,the First Affiliated Hospital of Nanjmg Medical University,Nanjing 210029,Jiangsu Province,China;Department of Anesthesiology,the First Affiliated Hospital of Nanjmg Medical University,Nanjing 210029,Jiangsu Province,China
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摘要
Abstract
Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.关键词
urapidil/nicardipine/sinus function/A-V node function/hemodynamicsKey words
urapidil/nicardipine/sinus function/A-V node function/hemodynamics分类
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..The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics[J].南京医科大学学报（英文版）,2007,21(6):386-389,4.
