中国临床康复2004，Vol.8Issue(19)：3908-3909,2.
黄芩茎叶总黄酮对小鼠脑缺氧的保护作用
Protective effects of total flavonoids from stems and leaves of Scutellaria baicalensis George on cerebral hypoxia in mice
商亚珍 1曹凯1
作者信息
- 1. 承德医学院中药研究所,河北省,承德市,067000
- 折叠
摘要
Abstract
BACKGROUND: Total flavonoids from stems and leaves of Scutellaria baicalensis George(TF) can enhance and improve learning and memory abilities in experimental animal, and reduce the neuronal pathological alteration induced by D-galactose in mice. It is elucidated further the improving effect of TF on memory ability in cerebral hypoxic mice caused by peritoneal injection NaNO2 and decapitation.OBJECTIVE: To study the protective effects of TF on cerebral hypoxia in mice.DESIGN: A completely randomized control trial study.SETTING and MATERIALS: One hundred Kunming mice provided by the Experimental Animal Center, Institute of Chinese Materia Medica,Chengde Medical College were conduced in biochemical laboratory of Institute of Chinese Materia Mediea of Chengde Medical College.INTERVENTIONS: Mice were orally administered TF(50, 100 and200 mg/kg, once a day) and Piracetam(PIR, 200 mg/kg) for 7 days. The mice were injected NaNO2 and decapitated 60 minutes after last adninistration, respectively.MAIN OUTCOME MEASURFS: The mice' s survival time after peritoneal injection NaNO2 and gasping duration after decapitation were as index.RESULTS: Daily oral administration of TF(50, 100 and 200 mg/kg) for7 days could dramatically prolong the survival time after peritoneal injection NaNO2 and the gasping duration after decapitation in mice. Compared with the mice in control group, the survival time after peritoneal injection NaNO2prolonged 25.3 %, 50.2 % and 68.3 %, and the gasping duration was found 1.00, 1.07 and 1.48 times, respectively. PIR also revealed the strong anti-hypoxic effects.CONCLUSION: TF exerts protective effects on cerebral hypoxia in mice.关键词
黄芩/缺氧,脑/小鼠分类
医药卫生引用本文复制引用
商亚珍,曹凯..黄芩茎叶总黄酮对小鼠脑缺氧的保护作用[J].中国临床康复,2004,8(19):3908-3909,2.
