中德临床肿瘤学杂志（英文版）2006，Vol.5Issue(6)：391-395,5.
促血管生成素及其受体的异常表达与胃癌血管生成的关系
Angiopoietins/Tie-2 expression and angiogenesis in stomach carcinoma
摘要
Abstract
Objective: To explore angiopoietins (Ang-1, Ang-2//Tie-2 expression and angiogenesis in stomach carcinomas.Methods: RT-PCR and immunohistochemistry were used to detect angiopoietins/Tie- 2 mRNA and protein expression in stomach carcinomas and their adjacent normal mucosa. Microvessel density (MVD) was counted according to CD34 immunohistochemical staining. Results: There was positive expression of Angiopoietins/Tie-2 mRNA and protein in stomach carcinomas and their paired adjacent normal mucosa. It was found that correlation between Ang-1 protein, Tie-2 mRNA expression and MVD was negative (r=-0.440, r=-0.267;P＜0.05), while the correlation between Ang-2 mRNA and its protein, Ang-2/Ang-1 protein ratio and MVD was positive (r=0.319,r=729,r=739; P＜0.05). Moreover, MVD in groups with Ang-2 mRNA T/N ratio over 1.2 (the ratio of Ang-2 mRNA in stomach carcinoma to its adjacent normal mucosa) was higher than those with the ratio under 1.2. Conclusion:It was suggested that Ang-1 and Ang-2 antagonizes in the angiogenesis and the angiogenesis in tumor ultimately depended on Ang-2/Ang-1 ratio, once the expression of Ang-2 is higher than Ang-1 in some degree, the angiogenesis in tumors was promoted,otherwise oppositely. In other words, Ang-2 plays dominant role in the action of angiogenesis in tumors.关键词
angiopoietins (Ang-1 and Ang-2)/tie-2/stomach neoplasmKey words
angiopoietins (Ang-1 and Ang-2)/tie-2/stomach neoplasm分类
医药卫生引用本文复制引用
张真真,张声,林建银..促血管生成素及其受体的异常表达与胃癌血管生成的关系[J].中德临床肿瘤学杂志（英文版）,2006,5(6):391-395,5.基金项目
Supported by a grant from the Natural Sciences Foundation of Fujian(No. C0110013). （No. C0110013）
