首页|期刊导航|中华医学杂志（英文版）|Effects of extract of Ginkgo biloba with venlafaxine on brain injury in a rat model of depression
中华医学杂志（英文版）2005，Vol.118Issue(5)：391-397,7.
Effects of extract of Ginkgo biloba with venlafaxine on brain injury in a rat model of depression
Effects of extract of Ginkgo biloba with venlafaxine on brain injury in a rat model of depression
摘要
Abstract
Background Recent studies have indicated that chronic stress may give rise to brain damage, which is related to the genesis of depression. The purpose of this study is to investigate the effects of extract of Ginkgo biloba (EGb) and venlafaxine on depression.Methods Rats were treated with chronic and comprehensive stress to create a depression model. Immunohistochemistry was used to detect the expression of brain-derived neurotrophic factor (BDNF) in the hippocampal CA3 neurons of rats treated with different drugs. Behavioral changes of these rats were also examined. Results The expression of BDNF in the hippocampal CA3 neurons of the depression model decreased with a reduction in exploring behavior and a significant increase in fecal production. The expression of neuron nitric-oxide synthase (nNOS) protein also increased in the rats compared to normal controls. The rats treated with EGb and venlafaxine showed an increase in expression of BDNF and exploring behavior compared to untreated rats, but a decrease in nNOS and fecal production.Conclusions Rats sustain damage to the brain after being subjected to chronic and comprehensive stress. Our research has indicated that combined EGb with venlafaxine enhances the protection of neurons and decreases damage to the brain, while relieving the side effects of synthetic antidepressants.关键词
stress/depression/Ginkgo biloba extract/nitric-oxide synthase/brain-derived neurotrophic factor/brain injuryKey words
stress/depression/Ginkgo biloba extract/nitric-oxide synthase/brain-derived neurotrophic factor/brain injury分类
医药卫生引用本文复制引用
QIN Xiao-song,JIN Kui-he,DING Bao-kun,XIE Shou-fu,MA Hui..Effects of extract of Ginkgo biloba with venlafaxine on brain injury in a rat model of depression[J].中华医学杂志（英文版）,2005,118(5):391-397,7.基金项目
This work was supported by a grant from the Liaoning Science and Technology Program (No. 2002225003-4). （No. 2002225003-4）
