现代妇产科进展2002，Vol.11Issue(5)：398-400,3.
The decrease of serum vascular endothelial growth factor concentration in patients with pregnancy induced hypertension
The decrease of serum vascular endothelial growth factor concentration in patients with pregnancy induced hypertension
摘要
Abstract
Objectives:To detect the concentration of serum vascular endothelial growth factor (VEGF) in patients with pregnancy induced hypertension (PIH) as well as to explore the role of VEGF in the pathogenesis of PIH.Methods:Serum VEGF concentrations in 23 healthy nonpregnant women (normal group),30 normal pregnant women (control group) and 37 women with PIH (PIH group) were measured by sandwich enzyme-linked immunoadsorbent assay (ELISA).Results:Serum concentrations of VEGF in control group were significantly higher (149.39±27.15ng/L) than those in normal group (11.98±3.99ng/L) (P＜0.001),peaking in the second trimester of pregnancy (183.84±49.02ng/L) and decreasing in the third trimester (118.37±34.29ng/L).Serum VEGF concentrations (64.45±24.33ng/L) in PIH group were significantly lower than those in normal late pregnancy women of control group (118.37±34.29ng/L) (P＜0.01).There was a trend that serum VEGF concentrations in PIH group decreased with the severity of PIH (P＜0.05).Conclusion:The serum VEGF concentration in PIH women are significantly decreased,which suggests that VEGF may play an important role in the pathogenic mechanism of PIH.关键词
Pregnancy/Complications/Pregnancy induced hypertension/Endothelial growth factorKey words
Pregnancy/Complications/Pregnancy induced hypertension/Endothelial growth factor分类
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..The decrease of serum vascular endothelial growth factor concentration in patients with pregnancy induced hypertension[J].现代妇产科进展,2002,11(5):398-400,3.基金项目
This study was supported by Medical Science Technique Foundation of Guangdong Province (970035) （970035）
