天然产物研究与开发2006，Vol.18Issue(3)：398-400,404,4.
白藜芦醇苷对血栓形成及血浆TXB2和6-keto-PGF1α水平的影响
Investigation of Polydatin on Antithrombotic Effects and Plasma Levels or TXB2 and 6-keto-PGF1α
摘要
Abstract
Antithrombotic effects of polydatin(PD) and its influence on plasma thromboxane B2 (TXB2) and 6-keto-prostaglandin F1α(6-keto-PGF1α) leves were investigated. The methods of injection of arachidonic acid (AA) into mouse vein and electrically stimulated carotid thrombosis in rats were used to evaluate the antithrombotic effects of PD; TXB2 and 6-keto-PGF1α levels were monitored by the radioimmunoassay. The results showed that PD obviously protected against thrombosis caused by AA and electrical stimulation. PD also significantly decreased plasma TXB2 level and increased plasma 6-keto-PGF1α level simultaneously. It is suggested that polydatin should have evident antithrombotic effects and the mechanisms may be intimately related to its decrease of plasma TXB2 and increase of 6-keto-PGF1α.关键词
白藜芦醇苷/血栓形成/花生四烯酸/血栓素B2/6-酮-前列腺素F1αKey words
polydatin/thrombosis/arachidonic acid/thromboxane B2/6-keto-prostaglandin F1α分类
医药卫生引用本文复制引用
陈鹏,杨丽川,胡晓立,雷伟亚,沈志强..白藜芦醇苷对血栓形成及血浆TXB2和6-keto-PGF1α水平的影响[J].天然产物研究与开发,2006,18(3):398-400,404,4.基金项目
The project is supported by Natural Science Foundation of Yunnan Province (No.2004C0019Q) and Opening Foundation of Yunnan Pharmacological Laboratories of Natural Products(No.98KZ01). （No.2004C0019Q）
