中华医学杂志（英文版）2002，Vol.115Issue(3)：402-404,3.
脱氢表雄酮硫酸酯治疗男性骨质疏松症的临床观察
Treatment of osteoporosis in men using dehydroepiandrosterone sulfate
摘要
Abstract
Objective To study the effect of dehydroepiandrosterone sulfate (DHEAS) treatment of osteoporosis in men with TBMD≥2.5SD. Methods Eighty-six patients were randomly divided into two groups: treatment group (n=44) and control group (n=42). DHEAS (100?mg q.d.) was given to the treatment group for 6 months. Bone mineral density, (BMD), biochemical markers of bone absorption and formation and other serum biochemical markers were measured before and after DHEAS treatment. Drug side effects were also evaluated. Results After oral administration of DHEAS (100?mg q.d.) for 6 months, the serum concentrations of DHEAS and IGF-Ⅰ in the treatment group were 93.75%±16.1% and 17.71%±4.2% higher respectively than those in the control group (P<0.01). The BMD of L2, L3, L4, L2-4 and Neck sections increased in the treatment group by 2.65%±0.65%, 2.70%±0.48%, 3.10%±0.41%, 2.82%±0.37% and 2.32%±0.31%, respectively, as compared with that the control group (P<0.05 or 0.01). No significant changes were observed in serum FT, E2 and PSA concentrations in the treatment group as compared with the control group. Conclusion The treatment of osteoporosis in men with DHEAS is safe and effective.关键词
脱氢表雄酮/脱氢表雄酮硫酸酯/骨质疏松症/骨密度Key words
dehydroepiandrosterone/dehydroepiandrosterone sulfate/osteoporosis分类
医药卫生引用本文复制引用
孙宜萍,毛敏伟,孙丽华,冯缨缨,杨建芬,沈佩华..脱氢表雄酮硫酸酯治疗男性骨质疏松症的临床观察[J].中华医学杂志（英文版）,2002,115(3):402-404,3.基金项目
This project was granted by Shanghai Science Committee (No. 964119024). （No. 964119024）
