基础医学与临床2001，Vol.21Issue(1)：40-42,3.
载脂蛋白E基因多态性与中国人阿尔茨海默病 和颈动脉粥样硬化相关性研究
Association between ApoE gene polymorphism and Alzheimer’s disease and Carotic arteriosclerosis in Chinese
摘要
Abstract
To investigate the relationship between apoE gene polymorphism and sporadic Alzheimers disease（SAD） and Carotic arteriosclerosis (CAS). ApoE gene distribution was determined using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique in 46 SAD, 31 CAS and 50 normal controls. The ApoE 4 allele frequency was increased in both SAD and CAS as compared to controls. While the ApoE 2 allele frequency was much higher in CAS as compared to SAD. The ApoE 4 allele of ApoE gene may be risk factors for both SAD and CAS in Chinese, while the ApoE 2 allele genes may protect CAS individuals from SAD.关键词
ApoE基因/阿尔茨海默病/动脉粥样硬化分类
医药卫生引用本文复制引用
杨静芳,陈彪,柏华,董秀敏,武剑,陈保生,贾建平..载脂蛋白E基因多态性与中国人阿尔茨海默病 和颈动脉粥样硬化相关性研究[J].基础医学与临床,2001,21(1):40-42,3.基金项目
北京市卫生局重点学科项目资助 （）
