南京医科大学学报(英文版)2004，Vol.18Issue(1)：40-43,4.
莲必治注射液(穿心莲内酯)对免疫功能的调节作用
Modulation of Lianbizi Injection (Andrographolide) on Some Immune Functions
周锋 1秦健 2朱建中 1彭光勇 1孙华 1丁如宁 1李焕娣 1姚堃1
作者信息
- 1. 南京医科大学微生物与免疫学系,南京,210029
- 2. 河海大学人文学院英语系,南京,210024,中国
- 折叠
摘要
Abstract
Objective: To study the effects of andrographolide on immune functions and the immune mechanism in clinical therapy. Methods: The amounts of IFN-α, IFN-γ, TNF-α, IL-8 in the peripheral blood mononuclear cells ( PBMC) culture supernatants dealt with by different concentrations of LianBiZhi (LBZ) injection, the effective component of which is andrographolide,were detectedby biological activity test or ELISA in vitro. The effects of LBZ injection on macrophage phagocytotic function and natural killer cells cytotoxicity were examined by means of macrophage to phagocytize cock erythrocyte and measurement of lactate dehydrogenase (LDH) activity released from the damaged cells, respectively. Results: The LBZ injection could not only enhance the phagocytosis activity of peritoneal macrophage from guinea pig to phagocytosis cock erythrocytes, but also augment the cytotoxicity mediated by natural killer cells from PBMCs. Conclusion: Andrographolide is an immunostimulant agent which can modulate both antigen specific and nonspecific immune function by means of its natural killer cells, macrophage and cytokines.关键词
穿心莲内酯/莲必治注射液/单核巨噬细胞/NK细胞/细胞因子/免疫功能Key words
andrographolide/Lianbizi injection/macrophage/natural killer cell/cytokines/immune function分类
医药卫生引用本文复制引用
周锋,秦健,朱建中,彭光勇,孙华,丁如宁,李焕娣,姚堃..莲必治注射液(穿心莲内酯)对免疫功能的调节作用[J].南京医科大学学报(英文版),2004,18(1):40-43,4.
