解剖学杂志2000，Vol.23Issue(5)：404-407,4.
一氧化氮合酶抑制剂N-硝基-L-精氨酸甲基酯对大鼠淋巴管运动的影响
EFFECT OF NITRIC OXIDE SYNTHASE INHIBITOR L-NAME ON RATS' MESENTERIC LYMPHATIC MOTION
摘要
Abstract
Objective: To study the effect of NG-nitro-L-arginine methyl ester(L-NAME), one of theinhibitors of NOS, on rats' mesenteric lymphatic vessels. Methods: L-NAME was injectedthrough femoral vein. Rtas' mesenteric lymphatic vessels were inspected within 2 hours in vivo.Paraffin section for HE stain, frozen section for NADPH diaphorase histochemistry stain, werecarried out to inspect its tissue change. Results: After injected L-NAME, the mesenteric lym-phatic diameter was smaller than normal and the motive frequency was increased, could be tem-porarily restored those change by administration of L-arginine; NOS was found in lymphatic en-dothelia and the nerve fibers in the vessels' wall under microscope; In HE sections, the dilation ofvilli central lacteal of small intestinal tunica mucosa was found in L-NAME in jection group, sug-gesting that the transporting function of lymphatic vessels decreased. Conclusion: NO plays animportant roles in the regulation lymphatic circulation.关键词
淋巴管/一氧化氮合酶/N-硝基-L-精氨酸甲基酯/大鼠Key words
lymphatic vessel/nitric oxide synthase(NOS)/NG-nitro-L-arginine methyl ester(L-NAME)引用本文复制引用
王宝恒,张立平,史桂芝,于桂英,李振平..一氧化氮合酶抑制剂N-硝基-L-精氨酸甲基酯对大鼠淋巴管运动的影响[J].解剖学杂志,2000,23(5):404-407,4.基金项目
国家自然科学基金资助项目(No.39370369) （No.39370369）
