生命科学研究2002，Vol.6Issue(1)：40-45,6.
应用贝叶斯理论推断DNA分子标记基因型
Inferring Genotype of DNA Molecular Marker by Bayesian Theorem
摘要
Abstract
Bayesian theorem is applied to infer the DNA molecular marker genotype(DNA chain type) from its phenotype (electrophoresis band type). The results indicated that large differences often present in the genotype probability of a molecular marker with incomplete genetic information when it is obtained from the assumption of independence among markers as compared with that inferred from the genotypes of the flanking markers with the complete genetic information and the recombination fractions among them based on the Bayesian theorem. Therefore, before utilizing the marker information, such as in mapping quantitative trait loci (QTL), marker assisted selection (MAS) etc., Bayesian probability of the genotype for all markers with incomplete genetic information must be calculated over the whole genome for every individual. This study provides detailed procedure for the calculation of the Bayesian probability of the unknown genotype. Several extensions were also discussed for the application of the Bayesian theorem.关键词
贝叶斯概率/DNA标记/遗传信息不完全Key words
Bayesian probability/DNA marker/incomplete genetic information分类
生物科学引用本文复制引用
莫惠栋,姜长鉴..应用贝叶斯理论推断DNA分子标记基因型[J].生命科学研究,2002,6(1):40-45,6.基金项目
国家自然科学基金资助项目(39670391) （39670391）
