天然产物研究与开发2006，Vol.18Issue(3)：405-407,417,4.
海洋来源放线菌3275化学成分及抗肿瘤活性研究
Studies on the Chemical Constituents and Antitumor Activity of Secondary Metabolites of Marine-derived Streptomyces sp. 3275
摘要
Abstract
In order to find bioactive compounds, the secondary metabolites of the fermentation of actinomycete streptomyces sp.3275 were studied,Among seven compounds were isolated from the active extract by repeated chromatography over silica gel,sephadex LH-20 column and HPLC. Their structures were identified on the basic of comparison to literature and spectroscopic analysis as cyclo (Val-Pro) (1), cylco (Pro-Tyr) (2), cyclo (Gly-Pro) (3), cyclo (Pro-Ile) (4), cyclo (Leu-Pro) (5),cholest-5-en-3β-ol (6), 1-methyl- 1,2,3,4-tetrahydro-carboline-3-carboxylic acid (7). Compounds 2,3,5 exhibited weak cytotoxicities against tsFT210 cell line.关键词
海洋来源放线菌/链霉菌/次级代谢产物/抗肿瘤活性Key words
marine-derived actinomycete/Streptomyces sp./secondary metabolites/antitumor activity分类
生物科学引用本文复制引用
赵文英,朱天骄,古静燕,顾谦群,朱伟明..海洋来源放线菌3275化学成分及抗肿瘤活性研究[J].天然产物研究与开发,2006,18(3):405-407,417,4.基金项目
This research are financially supported by National 863 Project (2003AA624020), National Natural Science Foundation of China ( No.30472136 & 30470196), Qingdao Natural Science Foundation (04-2-JZ-81). （2003AA624020）
