中国实用口腔科杂志2009，Vol.2Issue(7)：415-417,3.
MMP-2和MVD在腺样囊性癌中的表达及临床意义
Expression and clinical significance of MMP-2 and MVD in adenoid cystic carcinoma.
芦杨 1齐鸿亮1
作者信息
- 1. 山西医科大学第一临床医学院口腔科,太原030001
- 折叠
摘要
Abstract
Objective To study the expression and clinical significance of matrix metalloproteinase-2 (MMP-2) and endoglin(CD105)in cancer of adenoid cystic carcinoma (ACC) and explore the correlation of MMP-2 with MVD which was marked by CD105. Methods Immunohistochemistry was used to measure the expression of CDI05 and MMP-2 in normal tissues of salivary gland, pleomorphic adenoma (PA) and adenoid cystic carcinoma (ACC), calculation of M VD and MMP-2;the data was analyzed by SPSS(13.0) software. Results The difference of the MVD in the normal tissues of salivary gland, pleomorphic adenoma and adenoid cystic carcinoma was significant, so was MMP-2; the count of MVD showed significant correlation with size of the tissues , stage of the disease , type of pathological and neurological symptoms (P < 0.05) ; the difference of M M P-2 in different types of pathological and sizes of the tissues were significant (P < 0.05) ;the difference of MVD which was divided by the count of MMP-2 was significant (P < 0.05). Conclusion MMP-2 and CD105 are highly expressed in adenoid cystic carcinoma tissues at protein level; the MVD marked by CD 105 significantly correlates with M M P-2;they might become promising targets for adenoid cystic carcinoma.关键词
腺样囊性癌/MMP-2/免疫组织化学/CD105/MVDKey words
adenoid cystic carcinoma/matrix metalloproteinase-2/immunohistochemistry/CD 105/MVD分类
医药卫生引用本文复制引用
芦杨,齐鸿亮..MMP-2和MVD在腺样囊性癌中的表达及临床意义[J].中国实用口腔科杂志,2009,2(7):415-417,3.
