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Steroids from green alga Chaetomorpha basiretorsa Setchell

SHI Dayong FAN Xiao SUN Jie HAN Lijun SHI Jiangong

中国海洋湖沼学报(英文版)2008,Vol.26Issue(4):415-418,4.
中国海洋湖沼学报(英文版)2008,Vol.26Issue(4):415-418,4.DOI:10.1007/s00343-008-0415-7

Steroids from green alga Chaetomorpha basiretorsa Setchell

Steroids from green alga Chaetomorpha basiretorsa Setchell

SHI Dayong 1FAN Xiao 1SUN Jie 1HAN Lijun 1SHI Jiangong2

作者信息

  • 1. Institute of Oceanology. Chinese Academy of Sciences, Qingdao 266071, China
  • 2. Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 10005, China
  • 折叠

摘要

Abstract

Six steroids have been isolated from ethanolic extract of green alga Chaetomorpha basiretorsa Setehell by a combination of repeated normal phase silica gel and Sephadex LH-20 gel column chromatography as well as recrystallization. Using spectroscopic methods including MS and NMR, their structures were determined as β-lawsaritol (1), saringosterol (2), 24-hydroperoxy-24-vinyl-cholesterol (3), β-stigmasterol (4), stigmast-4-en-3α, 6β-diol (5), 29-hydroxystigmasta-5, 24 (28)-dien-3β-ol (6). All these compounds were obtained from this genus for the first time and they were inactive (IC5010 μg/ml) against KB, Bel-7402, PC-3M, Ketr 3 and MCF-7 cell lines.

关键词

green alga/Chaetomorpha basiretorsa Setchell/steroids

Key words

green alga/Chaetomorpha basiretorsa Setchell/steroids

分类

地球科学

引用本文复制引用

SHI Dayong ,FAN Xiao ,SUN Jie,HAN Lijun,SHI Jiangong..Steroids from green alga Chaetomorpha basiretorsa Setchell[J].中国海洋湖沼学报(英文版),2008,26(4):415-418,4.

基金项目

High Technology Research and Development Program of China (863 Program) (No. 2007AA09Z410 and 2007AA091604), NSFC of China (No.30530080) and the Key Innovative Program, Chinese Academy of Sciences (No. KZCX2-YW-209). (863 Program)

中国海洋湖沼学报(英文版)

OACSCDCSTPCD

2096-5508

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