中德临床肿瘤学杂志（英文版）2006，Vol.5Issue(6)：416-419,4.
阿糖胞苷和泰素在不同靶细胞生长状态下具有不同细胞周期特异性
Cytarabine and paclitaxel exhibit different cell-cycle specificities in different cell growing status
摘要
Abstract
Objective: To investigate the cell-cycle specificities of cytarabine and paclitaxel in different growing status of target cell. Methods: Using flow cytometry, we tested the cell-cycle specificities of cytarabine and paclitaxel on acute lymphocyte leukemia cell line Molt-4 in different growing status and on clinical acute lymphocyte leukemia specimens in vitro as well as in leukemia patients in vivo. Results: Cytarabine induced S phase specific cell-cycle blockage and apoptosis in exponentially growing Molt-4, but showed G0/G1 phase specificity in high-density cultured Molt-4 and in clinical specimens. Paclitaxel induced G2/M phase specific cell-cycle blockage and apoptosis in exponential Molt-4, but showed G0/G1 phase specificity in high-density cultured Molt-4 and S phase specificity in clinical specimens. In the first day of clinical chemotherapy, cytarabine induced G0/G1 with a little S phase apoptosis in leukemia cells of acute lymphocyte leukemia patient in vivo. Cytarabine plus paclitaxel together had almost the same effect in the second day. Conclusion: The cell-cycle effects of cytarabine and paclitaxel were different in different target cell growing status. It should be noted that the in vivo effect of these agents may be different from people usually anticipated during clinical chemotherapy. So the combined chemotherapeutic regimens may need to be redesigned.关键词
cell cycle/apoptosis/leukemia/cytarabine/paclitaxelKey words
cell cycle/apoptosis/leukemia/cytarabine/paclitaxel分类
医药卫生引用本文复制引用
张鹏,周毅,陶德定..阿糖胞苷和泰素在不同靶细胞生长状态下具有不同细胞周期特异性[J].中德临床肿瘤学杂志（英文版）,2006,5(6):416-419,4.基金项目
Supported by grants from the National Natural Sciences Foundation of China (No. 30570908) and China Key Basic Research Program (No. 2004CB518705). （No. 30570908）
