中国当代儿科杂志2009，Vol.11Issue(6)：417-421,5.
儿童过敏性紫癜性肾炎血管内皮生长因子基因多态性的研究
Gene polymorphism of vascular endothelial growth factor in children with Henoch-Schonlein purpura nephritis
摘要
Abstract
Objective To study the relationship of -634G/C gene polymorphism of vascular endothelial growth facto (VEGF) with Henoch-Schonlein purpura nephritis (HSPN) in children. Methods One hundred ethnic Han children with HSP, including 50 children with concurrent nephritis (HSPN group) and 50 children without nephritis (HSP without nephritis group), were enrolled. Fifty age-, sex- and ethnics-matched healthy children were used as the control group. VEGF-634G/C genotypes were determined by PCR-RFLP. Plasma VEGF levels were measured using ELISA. Results CC genotype distribution (32%) and C allele frequency (56%) in the HSPN group were significantly higher than those in the control group ( 10% and 35% respectively) and the HSP without nephritis group ( 10% and 33% respectively) (P <0.01 ). The incidence of nephritis in HSP patients with CC genotype increased significantly when compared with those with GG genotype (76% vs31%; P <0.01). Plasma VEGF levels in patients with CC genotype (180.5±40.7 pg/mL) were significantly higher than those in patients with CG (145.2 ±48.3 pg/mL) and GG (101.5 ±26.5 pg/mL) genotypes (P <0.05). Conclusions VEGF-634G/C gene polymorphism may be associated with the development of HSPN. C allele may a susceptible gene of HSPN.关键词
过敏性紫癜性肾炎/基因多态性/血管内皮生长因子/儿童Key words
Henoch-Schonlein purpura nephritis/ Gene polymorphism/ Vascular endothelial growth factor/ Child分类
医药卫生引用本文复制引用
曾华松,熊小燕,陈耀勇,罗小平..儿童过敏性紫癜性肾炎血管内皮生长因子基因多态性的研究[J].中国当代儿科杂志,2009,11(6):417-421,5.基金项目
Scientific Research Foundation for Returned Scholars, Ministry of Personnel of China (No. 200499 ) （No. 200499 ）
The Key Grant of theGuangdong Provincial Government for Science and Technology ( No. 2003B30503 ) （ No. 2003B30503 ）
The General Grant of the Guangzhou City Governmentfor for Science and Technology ( No. 2005Z1 -E0104) （ No. 2005Z1 -E0104）
The Key Grant of Guangzhou City Health Bureau,China ( No. 2005-Zdi-08). （ No. 2005-Zdi-08）
