中国药科大学学报2005，Vol.36Issue(5)：417-422,6.
表面活性剂复配制备稳定的固体脂质纳米粒混悬液
Preparation of Stable Solid Lipid Nanoparticles (SLNs) Suspension with Combined Surfactants
摘要
Abstract
AIM:Surfactants and their blend play important roles in the preparation of solid lipid nanoparticles (SLNs).In this study,four types of surfactant were employed to investigate the influence of the surfactants on properties of SLNs in the absence of model drugs thereby avoiding the interaction between the surfactant and the drug.METHODS:The physicochemical properties of the colloidal systems,such as mean particle size,distribution range and Zeta potential,were investigated by laser diffractometry and the DSC analysis was performed as well.RESULTS:It was found that ionic surfactants,such as sodium deoxycholate, increased the Zeta potential of nanoparticles leading to improve the physical stability of the system.But it showed obviously relative low emulsification efficiency in the preparation.Non-ionic emulsifier,especially Pluronic F-68, offered additional steric stabilization effect avoiding aggregation of the fine particles in the colloidal system.CONCLUSION:The formulation in the study for the first time combined four types of additives including ionic surfactant (sodium deoxycholate),non-ionic emulsifier (Pluronic F-68 and Tween-80),and lecithin to obtain favorably stable nanosuspension,which could stabilize for more than six months without creaming.关键词
固体脂质纳米粒/表面活性剂混合物/Zeta电位Key words
Solid lipid nanoparticles (SLNs)/Surfactant mixture/Zeta potential分类
医药卫生引用本文复制引用
侯冬枝,谢长生,平其能..表面活性剂复配制备稳定的固体脂质纳米粒混悬液[J].中国药科大学学报,2005,36(5):417-422,6.基金项目
国家自然科学基金资助项目(No.50271029) This project was supported by the National Natural Science Foundation of China(No.50271029) （No.50271029）
