中国病理生理杂志2001，Vol.17Issue(5)：418-421,4.
大鼠纹状体I组代谢型谷氨酸受体激动引起动物向对侧旋转
Activation of group I metabotropic glutamate receptors in rat
striatum induces contralateral rotation
袁芳 1王忠诚 2徐立新 3王天佑 3张亚卓3
作者信息
- 1. 北京市神经外科研究所病理生理室
- 2. 首都医科大学
- 3. 北京市神经外科研究所病理生理室,
- 折叠
摘要
Abstract
AIM:To study the subtype of metabotropic glutamate receptors (mGluRs) which induce contralateral rotations of rats after mGluRs activation. METHODS:Turning movement was measured at 6 h after agonist or antagonist of mGluRs was microinjected into rat striatum. RESULTS:tACPD, an agonist of mGluRs, at 500 nmol and 1 000 nmol induced contralateral rotations of rats. L-AP3, MCPG and dantrolene attenuated the turning effect of tACPD. DHPG, a selective agonist of group I mGluRs, mimicked the effect of tACPD. The effect of DHPG was blocked by MCPG, LY367385 (antagonist of mGluR1) and MPEP (antagonist of mGluR5), and abolished by pretreatment with reserpine (5 mg/kg). CONCLUSION:These results indicated the activation of group I mGluRs in rat striatum induced turning effect, which may be associated with the mobilization of intracellular Ca2+ stores and dependant on the existence of dopamine.关键词
谷氨酸盐类/旋转/多巴胺分类
医药卫生引用本文复制引用
袁芳,王忠诚,徐立新,王天佑,张亚卓..大鼠纹状体I组代谢型谷氨酸受体激动引起动物向对侧旋转[J].中国病理生理杂志,2001,17(5):418-421,4.
