中国临床康复2003，Vol.7Issue(31)：4218-4219,2.
缺血缺氧新生鼠海马p-CREB的变化及神经节苷脂对其的影响
Effects of gangliosides on phosphorylated regulatory element-binding protein in CA1 of the hippocampus of neonatal hypoxic-ischemic rat
张红爱 1王玲 1李文联 1杨年娣 1冷立娟2
作者信息
- 1. 解放军第四军医大学唐都医院小儿科,陕西省西安市,710038
- 2. 解放军第四军医大学唐都医院心内科,陕西省西安市,710038
- 折叠
摘要
Abstract
AIM:To study the expression of phosphorylated regulatory element-binding protein(p-CREB) in hippocampus(CA1) of neonatal cerebral hypoxia-ischemia(HI,n=36) rat and the effect of gangliosides (GM1). METHODS:108 pieces of SD rats were randomly divided into three groups:control group(n=36),hypoxic-ischemia group(HI,n=36),and hypoxic-ischemia with GM1 group(GM1,n=36).The level of the p-CREB in hippocampus(CA1) were observed respectively at 1,4,12,24,48 and 72 hours after hypoxic-ischemia managements. RESULTS:The p-CREB levels in CA1 of control group had no difference at different times(P >0.05);the p-CREB level in CA1 f HI and GM1 group decreased quickly after a transient increase;there were significant differences between HI group and control group as well as between GM1 group and control group(P< 0.05);there was no significant difference between HI group and GM1 group(P >0.05). CONCLUSION:p-CREB level in CA1 of HI group decrease quickly after a transient increase compared with control group after HI management;the expression of p-CREB in CA1 is not suppressed by GM1,which is no harm to neurone survival,and therefore with potential clinical applications.关键词
神经节苷酯类/低氧-缺血,脑/载体蛋白质类分类
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张红爱,王玲,李文联,杨年娣,冷立娟..缺血缺氧新生鼠海马p-CREB的变化及神经节苷脂对其的影响[J].中国临床康复,2003,7(31):4218-4219,2.
