海洋水产研究2001，Vol.22Issue(1)：42-47,6.
土霉素在黑鲷体内的药物代谢动力学研究
Pharmacokinetic study of oxytetracycline in Black seabream
王群 1孙修涛 1刘德月 1刘琪 1李健1
作者信息
摘要
Abstract
This article is the first to report Pharmacokinetics property ofOTC in Black seabream after oral administration. OTC concentration was determ ined by high efficient liquid chromatography.The result demonstrated: data of OT C concentrations versus time conformed to the open dynamic model of one compart ment after a single oral administration at a dose of 75mg/kg, Absorption rate constant （ka）was 0.296/h, Time to reach maximum concentration （Tmax） was 10.635h, Maximum concentration（Cmax）was 1.398μg/ml, Absorption half-life（T1/2α）was 2.339h, Elimination half-life（ T1/2β）was 46.663h, Area under serum concentration (AUC) was 110. 25mg/L.h, we could determine the concentration of OTC in four ti ssues (muscle, blood, liver and kinedy) after 0.5h for administration and the m aximum concentration was 1.68、1.68、2.52、6.77μg/g respectively at 16h after a dministration,Average recoveries were 85.61%、85.38%、82.00% respective ly in muscle,blood and liver, and the limit of determination was 0.01μg/g.关键词
土霉素/黑鲷/药物代谢动力学分类
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王群,孙修涛,刘德月,刘琪,李健..土霉素在黑鲷体内的药物代谢动力学研究[J].海洋水产研究,2001,22(1):42-47,6.
