外科理论与实践2009，Vol.14Issue(4)：426-429,4.
羧甲基壳聚糖防粘连粉雾剂的应用及作用机制的研究
Study on the effect of carboxymethyl-chitosan in the prevention of postoperative abdominal adhesion and its mechanism of action
洪欣 1沈柏用 1韩宝三1
作者信息
- 1. 上海交通大学医学院附属瑞金医院器官移植中心,上海,200025
- 折叠
摘要
Abstract
Objective To investigate the effects of carboxymethyl-chitosan in the prevention of postoperative abdominal adhesion and its possible mechanism of action. Methods Sixty SD rats were randomly divided into 3 groups: control group 1 (open & close model) n=20, control group 2 (intestinal adhesion model) n=20 and experimental group (use of carboxymethyl-chitosan model) n=20. The degree and incidence of adhesion by the 7th day and 14th day after operation were compared respectively. The pathologic reaction of the peritoneum was observed under microscope. Results Conceming the incidence and the degree of adhesion. the control group 2 was higher than the others; in contrast the control groupl manifested the lowest degree. Conclusion Carboxymethyl-chitosan can significantly reduce the degree of postoperative adhesion in the abdomen.关键词
腹腔粘连/羧甲基壳聚糖/防粘连/光学显微镜Key words
Abdominal adhesion/ Carboxymethyl-chitosan/ Prevention of adhesion/ Microscopy分类
医药卫生引用本文复制引用
洪欣,沈柏用,韩宝三..羧甲基壳聚糖防粘连粉雾剂的应用及作用机制的研究[J].外科理论与实践,2009,14(4):426-429,4.
