天津中医药2004，Vol.21Issue(5)：426-429,4.
抗菌剂合用对芍药甘草汤中甘草酸生物利用度的降低作用及减少该作用的方法Ⅱ:合用西药对于芍药甘草汤中甘草酸生物利用度的影响
Reduction of bioavailability of glycyrrhizin from Shaoyao-Gancao-Tang by co-administered synthetic drugs and ways of minimizing it (Part Ⅱ ) Effects of co-administered synthetic drugs on the bioavailability of glycyrrhizin from Shaoyao-Gancao-Tang Shaoyao
何菊秀 1谿忠人2
作者信息
- 1. 日本富山医科药科大学和汉药研究所和汉药制剂开发部门,富山,930-0194,日本
- 2. 日本富山医科药科大学21世纪COE工程采用点,富山,930-0194,日本
- 折叠
摘要
Abstract
In part Ⅰ, we reported that the repetitive administration of Shaoyao-Gancao-Tang (SGT) increased the bioavailability of glycyrrhizin (GL) in SGT. In clinic, SGT is sometimes used together with some synthetic drugs. In this part Ⅱ , the influences of co-administered synthetic drugs on the pharmacokinetic fate of GL from SGT were investigated. The results showed that the co-administration of either a histamine2-receptor antagonist (cimetidine) or an anticholinergic drug (scopolamine butyl bromide, SBB) did not clearly influence the bioavailability of GL in SGT. However, the co-administration of a triple therapy OAM consisting of a proton pump inhibitor (omeprazole, OPZ) and two antibacterial drugs(amoxicillin, AMPC, and metronidazole, MET) markedly reduced the plasma GA concentration. The reduction of plasma GA by OAM was shown to be due to the antibacterial drugs AMPC-MET, not the proton pump inhibitor OPZ. The mechanism of the reduction by AMPC-MET involved the severe decrease of the GL-metabolizing activity of intestinal bacteria by AMPC-MET.These results suggest that it is not appropriate to simultaneously administer AMPC-MET with SGT.关键词
药物相互作用/芍药甘草汤/西药/甘草酸/药动学/肠内细菌/代谢活性Key words
drug-drug interaction/Shaoyao-Gancao-Tang/antibacterial drugs/glycyrrhizin/pharmacokinetics: intestinal bacteria分类
医药卫生引用本文复制引用
何菊秀,谿忠人..抗菌剂合用对芍药甘草汤中甘草酸生物利用度的降低作用及减少该作用的方法Ⅱ:合用西药对于芍药甘草汤中甘草酸生物利用度的影响[J].天津中医药,2004,21(5):426-429,4.
