解剖学杂志2000，Vol.23Issue(5)：428-431,4.
脑缺血海马CA1区5-HT变化的免疫组织化学研究
IMMUNOHISTOCHEMICAL STUDY ON CHANGE OF 5-HT IN CA1 SECTOR OF HIPPOCAMPUS FOLLOWING CEREBRAL ISCHEMIA
郭泽云 1吴春云 1李素华 1李玲 2陈植和2
作者信息
- 1. 昆明医学院组织学与胚胎学教研室，昆明 650031
- 2. 昆明医学院天然药物重点实验室
- 折叠
摘要
Abstract
Objective: To observe the change of 5-HT in CA1 sector of hippocampus in gerbils followingcerebral ischemia and reperfusion for discussing the relationship between the damage of neuronsin CA1 sector and the change of 5-HT after cerebral ischemia. Methods: The change of 5-HT inCA1 sector of hippocampus in gerbils following cerebral ischemia and reperfusion was examinedby ABC method of immunohistochemistry and image analysis technique. Results: (1) The meanvalue of optic density (OD) of 5-HT immunoreaction fiber in CA1 sector had no significant difference between the 10 min ischemic treated group and control group, whereas the OD of 5-HT wasdecreased significantly in 30 min and 4 h ischemia treated group. (2) The OD of 5-HT immunoreaction fiber in CA1 was decreased in 10 min cerebral ischemia following 30 min and 4 h reperfusion and was the lowest after 24 h reperfusion. After 36 h reperfusion, the OD became normalgradually. Conclusion: The content of 5-HT in CA1 sector of hippocampus is decreased in cerebral ischemia and reperfusion. The change of 5-HT may be involved in neuron damage of CA1 incerebral ischemia and reperfusion.关键词
脑/海马/脑缺血/5-羟色胺/沙土鼠Key words
brain/hippocampus/cerebral ischemia/serotonin/gerbils引用本文复制引用
郭泽云,吴春云,李素华,李玲,陈植和..脑缺血海马CA1区5-HT变化的免疫组织化学研究[J].解剖学杂志,2000,23(5):428-431,4.
