中国药科大学学报2003，Vol.34Issue(5)：433-437,5.
氯诺昔康固体分散体的热焓变化及溶出度改善特性
Characteristics of Enthalpy Change and Dissolution Improvement of Lornoxicam from Solid Dispersions
任秉钧 1张建军 2高缘 2俞建生1
作者信息
- 1. 浙江震元制药有限公司,绍兴,312000
- 2. 中国药科大学药剂学教研室,南京,210009
- 折叠
摘要
Abstract
AIM: Solid dispersions of water-insoluble lornoxicam were prepared in order to improve their dissolution rate.Dissolution study and differential scan calorimetry(DSC) study were performed to investigate the characteristics of enthalpychange and comparative dissolution improvement. METHOD: Lornoxicam solid dispersions were prepared by classical solventevaporation technique with PVP K-30, Gelucire 44/14 and poloxamer 188 as carriers. The effects of main process variables,including types of carriers and mixing ratios, on the physicochemical characteristics were investigated by dissolution study andDSC study. RESULT:The dissolution rate constants were olbserved to depend on the types of carriers and mixing ratios. Onsettemperature and entbalpy change of lornoxicam from DSC profiles were found to decrease significantly with the increase of mix-ing ratios. Lornoxicam can be converted to an amorphous state in crystalline PXM, which is consistent with the excellent disso-lution improvement of PXM coevaporates in vitro experiment. CONCLUSION: The types of carriers and drug-carrier ratio hadgreat effect on the characteristics of in vitro dissolution and enthalpy change of lornoxicam solid dispersion.关键词
氯诺昔康/泊洛沙姆/Gelucire(R) 44/14/聚乙烯吡咯烷酮/固体分散体Key words
Lornoxicam/Poloxamer/Gelucire 44/14/PVP/Solid dispersion分类
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任秉钧,张建军,高缘,俞建生..氯诺昔康固体分散体的热焓变化及溶出度改善特性[J].中国药科大学学报,2003,34(5):433-437,5.
