生殖医学杂志2006，Vol.15Issue(z1)：43-47,5.
The application of vitrification in human blastocyst cryopreservation: Analysis of clinical outcome of 117 cycles
The application of vitrification in human blastocyst cryopreservation: Analysis of clinical outcome of 117 cycles
Sun Zheng-yi 1He Fang-fang 1Yu Qi 1Deng Cheng-yan1
作者信息
- 1. Department of Obstetrics & Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730,China
- 折叠
摘要
Abstract
Objective: To summarize the clinical outcomes of 117 human vitrified blastocyst transfer cycles and to determine the impact factors.Methods: In IVF-ET cycles, supernumerary embryos were cultured to 5-Day(D5) or 6-Day(D6), blastocysts of various stages were cryopreserved by vitrification using cryoloops. Survival rate and clinical pregnancy rate were observed.Results: A total of 312 blastocysts were thawed in 117 frozen embryo transfer cycles, the survival rate was 90.7% (283/312) after thawing. After the transfer of 230 blastocysts in 115 cycles, 69.6% (80/115) of the women got clinically pregnant, and 17.5% (14/80) of them suffered from miscarriage, 39 healthy babies were born in 28 deliveries, and the other 38 pregnancies are ongoing. The implantation rate was 47.4% (109/230). In 107 transfer cycles with 2 hatched blastocysts transferred in each cycle, 72.9% (78/107) got clinically pregnant, while in 8 cycles with 1 or no hatched blastocysts in the two transferred blastocysts, the clinical pregnancy rate is 25%(2/8). The clinical pregnancy rates were not statistically different between natural (77.4%, 24/31) or artificial endometrium preparation (66.7%, 56/84) cycles. Conclusions: These findings suggest that blastocyst vitrification is effective in terms of implantation rate and pregnancy outcome. Transferring of two hatched blastocyst can achieve a higher pregnancy rate.关键词
Blastocyst/Cryopreservation/VitrificationKey words
Blastocyst/Cryopreservation/Vitrification分类
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Sun Zheng-yi,He Fang-fang,Yu Qi,Deng Cheng-yan..The application of vitrification in human blastocyst cryopreservation: Analysis of clinical outcome of 117 cycles[J].生殖医学杂志,2006,15(z1):43-47,5.
