解剖学杂志2000，Vol.23Issue(5)：436-438,3.
发育期大鼠实验性癫痫模型的建立
ESTABLISHMENT OF EXPERIMENTAL SETZURE MODEL IN DEVELOPMENTAL RATS
陈燕惠 1王丽2
作者信息
- 1. 福建医科大学附属协和医院儿科，福州 350001
- 2. 北京医科大学第一临床医院儿科
- 折叠
摘要
Abstract
Objective: To study kainic acid(KA)-induced seizures and explore condition of KA-inducedseizures in developing rats. Methods: Rats of postnatal ages (in 5, 15, 25, 60 days) were admin-istered KA intraperitoneally. Results: The dose of KA to induce seizures in different age-groupwas 1.4±0. 39, 2.5±0.67, 8.8±0. 79, 14±0. 67 mg · kg1 and the latency of seizure was 49.9±8.95, 60. 6±11.18, 65.9±10.04, 97.8±13.65±minutes. Keeping body of rats warm de-creased seizure mortality rate in puprats obviously. Conclusion: KA was an deal tool medicine toestablish experimental seizure model in developing rats from newborn to adult.关键词
发育/海人藻酸/癫痫/模型/大鼠Key words
development/kainic acid/eplepsy/model分类
医药卫生引用本文复制引用
陈燕惠,王丽..发育期大鼠实验性癫痫模型的建立[J].解剖学杂志,2000,23(5):436-438,3.
