首页|期刊导航|高技术通讯（英文版）|Discovering the cellular-localized functional modules and modular interactions in response to liver cancer
高技术通讯（英文版）2008，Vol.14Issue(4)：437-442,6.
Discovering the cellular-localized functional modules and modular interactions in response to liver cancer
Discovering the cellular-localized functional modules and modular interactions in response to liver cancer
摘要
Abstract
In this paper, we firstly identify the functional modules enriched with differentially expressed genes (DEGs) and characterized by biological processes in specific cellular locations, based on gene ontology (GO) and microarray data. Then, we further define and filter disease relevant signature modules according to the ranking of the disease discriminating abilities of the pre-selected functional modules. At last, we analyze the potential way by which they cooperate towards human disease. Application of the proposed method to the analysis of a liver cancer dataset shows that, using the same false discovery rate (FDR) threshold, we can find more biologically meaningful and detailed processes by using the cellular localization information. Some biological evidences support the relevancy of our biological modules to the disease mechanism.关键词
microarray/Gene Ontology/functional module/cellular location/liver cancerKey words
microarray/Gene Ontology/functional module/cellular location/liver cancer分类
信息技术与安全科学引用本文复制引用
Zhu Jing,Guo Zheng,Yang Da,Zhang Min,Wang Jing,Wang Chenguang..Discovering the cellular-localized functional modules and modular interactions in response to liver cancer[J].高技术通讯（英文版）,2008,14(4):437-442,6.基金项目
National High Technology Research and Development Programme of China (No. 2003AA2Z2051 （）
2002AA2Z2052) and the National Natural Science Foundation of China (No. 30170515 （）
30370388). （）
