中国药理学与毒理学杂志2002，Vol.16Issue(6)：438-442,5.
苄基四氢巴马汀对豚鼠心室肌细胞慢激活延迟整流钾电流及其尾电流的作用
Effects of benzyltetrahydropalmatine on slowly activating component of delayed rectifier K+ current and its tail current in guinea pig ventricular myocytes
摘要
Abstract
AIM To clarity the antiarrhythmic mechanisms of benzyltetrahydropalmatine (BTHP). METHODS Delayed rectifier potassium current (IKs) was recorded by using whole-cell patch clamp technique. RESULTS IKs was blocked by BTHP (1-100 μmol*L-1) in concentration-, voltage- and frequency-dependent fashion with an IC50 9.3 μmol*L-1 (95% confidence range: 7.8-11.8 μmol*L-1). BTHP 30 μmol*L-1 reduced IKs and its tail current(IKs,tail) by (40±6)% and (39±5)% (P<0.01). Time constants of deactivation of IKs,tail were reduced by BTHP, with accelerating deactivation course of IKs,tail. CONCLUSION BTHP inhibited IKs in isolated guinea pig ventricular myocytes.关键词
苄基四氢巴马汀/钾通道/慢激活延迟整流钾电流/膜片钳技术/心肌Key words
benzyltetrahydropalmatine/potassium channels/slowly activating component of delayed rectifier potassium current/patch clamp technique/myocardium分类
医药卫生引用本文复制引用
李泱,傅丽英,姚伟星,夏国瑾,江明性..苄基四氢巴马汀对豚鼠心室肌细胞慢激活延迟整流钾电流及其尾电流的作用[J].中国药理学与毒理学杂志,2002,16(6):438-442,5.基金项目
湖北省自然科学基金资助项目(99J154) （99J154）
