西安医科大学学报2000，Vol.21Issue(5)：439-441，487,4.
肺吸入胰岛素气雾剂对实验性糖尿病大鼠的治疗作用
Therapeutic effect of pulmonary inhaled insulin aerosol on rats of experimental diabe tes
李德强 1赵伯钦 1张南雁 1李晓芳1
作者信息
- 1. 第四军医大学西京医院内分泌科，西安710032
- 折叠
摘要
Abstract
Objective To observe the effect of reducing glycemia on rats suffering diabetes melli tus(DM). Methods We induced rats suffering DM by subcutaneous injecting tetraoxypyrimidine.Natrium glycocholate and natrium glycerate were chosen as respiratory tract musoca inhalant en hancer, and were made into inhaled insulin aerosol each other. The aerosol including natrium glyco cholate and natrium glycerate were administered to rats suffering DM after catheterization of bron chus. The level of glycemia was tested. Results We confirmed that rats suffering DM was a low
secretary insulin DM model. The aerosol that natrium glycocholate as inhalant enhancer acted in 15min and peaked in 30min after administration. The aerosol that natrium glycerate as inhalant en hancer acted in 15min and peaked in 2h after administration. The group subjected to subcutaneous injection insulin peaked in 1h after administration. The aerosol mentioned above were administrated to rats with DM in different dose of 5IU/kg, 10IU/kg, 15IU/kg. We observed that there was no significant enhancement of glycemia decreasing percent. Conclusion The pulmonary inhaled insulin aerosol which we made can obviously reduce glycemia.
关键词
肺/胰岛素气雾剂/大鼠/糖尿病Key words
pulmo/insulin aerosol/rats/diabetic mellitus分类
医药卫生引用本文复制引用
李德强,赵伯钦,张南雁,李晓芳..肺吸入胰岛素气雾剂对实验性糖尿病大鼠的治疗作用[J].西安医科大学学报,2000,21(5):439-441，487,4.
