解剖学杂志2000，Vol.23Issue(5)：439-442,4.
内毒素诱发肝性脑病大鼠脑超微结构观察
OBSERVATION ON CEREBRAL ULTRASTRUCTURE OFHEPATIC ENCEPHALOPATHY INDUCED BY ENDOTOXIN IN CIRRHOTIC RATS
李夏青 1韩德五1
作者信息
- 1. 山西医科大学病理生理学教研室，太原 030001
- 折叠
摘要
Abstract
Objective: The cerebral ultrastrunctural changes of hepatic encephalopathy(HE) in cirrhoticrats induced by endotoxin injection were investigated. Methods: Hepatic encephalopathy wereprecipated by endotoxin injection peritoneally into the cirrhotic rats( 3 mg/kg BW). The ultra-thin section from the cerebral cortex tissue were prepared and observed under electron mi-croscopy. Results: The mini blood vessels in the cortex of HE rats were expanded. There was anincrease of the cytoplasm folds of endothelium. The basement membrane under endothelial cellsshowed decreased electronic density or local degradation. The astrocytes and their processesaround mini blood vessels expressed a varity of edema, there was a decrease of cytoplasmic or-ganells and appearenee of matrix degradation. Conclusion: There are obvious changes in the cere-bral ultrastruncture in HE induced by endotoxin injection into cirrhotic rats. The changes implythat the there is a increased permeability of blood-brain barrier(BBB) in HE. Meantime, the glialcells show edema. The development of endotoxemia in HE may be the common base of all kindsof hypothesis about the pathogenesis of HE.关键词
内毒素/肝硬化Key words
liver/endotoxin/hepatic cirrhosis分类
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李夏青,韩德五..内毒素诱发肝性脑病大鼠脑超微结构观察[J].解剖学杂志,2000,23(5):439-442,4.
