中国输血杂志2009，Vol.22Issue(6)：439-443,5.
血液保存对红细胞携氧功能及能量代谢的影响
Effect of blood storage on RBC oxygen-carrying function and energy metabolism
摘要
Abstract
Objective To evaluate the impact of storage time and pre-treatment process on the oxygen-carrying func-tion and energy metabolism of red blood cells. Methods Oxygen-carrying capacity was measured by HEMOX-ANALYZ-ER, and the concentrations of glucose, Na+ ,K+ and lactate dehydrogenase were also detected at different storage time. Results The effective oxygen-carrylng volume of whole blood and suspended RBC decreased by 27.5% and 19.2%, re-spectively after 1 week, and at the end of preservation, the volume decreased to 39% and 51%, respectively. P50 values decreased during the preservation period, which was reduced sharply at the first two weeks, but then showed no significant change. Glucose level gradually reduced, and lactate dehydrogenase increased rapidly with storage time, and tripled at the end of storage. Na+ concentration declined, and K+ concentration gradually increased. K+ of suspension RBC also tripled at the end of storage. Conclusion Blood storage time and pre-treatment process have an important impact on RBC oxygen-carrying function and energy metabolism. Such treatments as filtration, centrifugatiun and others could result in a one-time injury to RBC.关键词
血液保存/红细胞/携氧功能Key words
Blood storage/ Red blood cell/ Oxygen-carrying function分类
医药卫生引用本文复制引用
李遥金,王翔,兰珂..血液保存对红细胞携氧功能及能量代谢的影响[J].中国输血杂志,2009,22(6):439-443,5.基金项目
国家自然科学基金项目(编号:10572159)及重庆市科委科技计划项目攻关项目(编号:2006ba5010) （编号:10572159）
