摘要
Abstract
Objective To observe clinical efficacy and safety of levonorgestrel-releasing intrauterine system (LNG-IUS). Methods 81 healthy women who only required contraception, 32 women with adenomyosis (AM) who required contraception and treatment, 6 women after conservative operation for endometriosis (EMs) who wanted an attempting treatment and 10 women with dysfunctional uterine bleeding (DUB) presenting menorrhagia (confirmed by diagnostic curettage and pathological examination) required treatment were inserted LNG-IUS into their uterine cavity timely and were regularily followed-up for contraceptive effect, menstruation, dysmenorrhea severity, size of uterine and endometrial thickness. Results The pregnancy rate in women carring LNG-IUS was 0. After 12 months treatment of LNG-IUS, the menstrual amounts of all women were reduced significantly to (8±3)% of that before treatment (P<0.01). The serum level of CA125 of the patients with AM dropped from 72±50kU/L to 31±24kU/L, and the difference was statistically significant (t=2.373,P<0.05). The endometrial thickness of patients with DUB was thinned from 13.2±5.1mm to 5.9±1.9mm, and the difference was statistically significant (t=3.452,P<0.01). The symptom dysmenorrhea of healthy women and patients with AM was completely remitted, while that of 4 patients with EMs was completely or remarkably remitted, and that of 2 patients with EMs was partly remitted. Conclusion LNG-IUS presents significant contraceptive effect and therapeutic effect for AM and DUB, also, it exerts certain therapeuitc effect for EMs.关键词
左炔诺孕酮/药物释放系统/子宫内膜异位症/功能失调性子宫出血/避孕Key words
levonorgestrel/drug releasing system/endometriosis(EMs)/dysfunctional uterine bleeding(DUB)/contraception分类
医药卫生
