现代康复2001，Vol.5Issue(10)：44-45,2.
纳洛酮对急性颈髓损伤后血浆及脑脊液中内皮素、降钙素基因相关肽含量的影响
Effect of naloxone on levels of endothlin-1 (ET-1) and alcitonin gene-related peptide (CGRP) in the plasma and cerebrospinal fluid(CSF) after acute cervical spinal cord injury
张建生 1罗晓阳2
作者信息
- 1. 兰州医学院第二附属医院
- 2. 解放军第四七三医院
- 折叠
摘要
Abstract
Objective The levels of endothelin-1(ET-1) and calcitonin gene-related peptide(CGRP) in the plasma and cerebrospinal fluid(CSF)after acute cervical spinal cord injury. Method ET-1 and CGRP were determined by RIA in order to observe the effects of naloxone on levels of ET-1 and CGRP and neuronal death of cervical spinal cord. Result Levels of ET-1 in the plasma and cerebrospinal fluid(CSF)after acute cerical spinal cord injury increased significantly; but the levels of CGRP in the plasma and cerebrospinal fluid(CSF) decreased markedly. The levels of ET-1 in the plasma and cerebropinal fluid(CSF)decreased markedly after the threapy of naloxone; but levels of CGRP in the plama and cerebrospinal fluid(CSF)increased sinificantly. Conclusion These deta suggest that the lessening of CGRP and increasing of ET-1 may be some important reson causing death of neuron after acute cervical spinal cord injury, and naloxone can protecet cervical spinal cord neuron by increasing levels of CGRP and decreasing levels of ET-1.关键词
颈髓损伤/血浆/脑脊液/内皮素/降钙素基因相关肽/纳洛酮分类
医药卫生引用本文复制引用
张建生,罗晓阳..纳洛酮对急性颈髓损伤后血浆及脑脊液中内皮素、降钙素基因相关肽含量的影响[J].现代康复,2001,5(10):44-45,2.
