广西科学1999，Vol.6Issue(1)：44-46,3.
P物质对大鼠星状神经节细胞的除极化
Depolarization Induced by Substance P on Rat Stellate Ganglion Neurons
摘要
Abstract
The effects of neuropeptide substance P(SP) on the neurons of the isolated stellate ganglia of the rat were investigated by means of intracellular recording techniques.At the concentration of 1 μm to 10 μm,SP caused a low,monophersic depolarization in 28 out of 35 cells tested, low Ca2+ or tetrodotoxin (TTX)-containing Kreb's solution did not cause any significant change of the amplitude or duration of SP-induced depolarization.SP-induced depolarization was often associated with an increase in membrane resistance.Generally,the response was reversed on membrane potential of -80 mV to -100 mV.It is concluded that SP is excitatory to stellate ganglionic neurons and serves to augment impulse transmission through the neurons.These findings also suggest that a reduction of membrane K + conductance may underline the depolarization action of SP.关键词
P物质/星状神经节/细胞生物电记录Key words
substance P/stellate ganglion/intracellular recording分类
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莫宁..P物质对大鼠星状神经节细胞的除极化[J].广西科学,1999,6(1):44-46,3.基金项目
国家自然科学资金(No.39470242)和广西科委匹配资金(No.9518018)资助项目. （No.39470242）
