中国肺癌杂志2001，Vol.4Issue(1)：44-46,3.
肺癌患者血中癌细胞端粒酶活性的检测
Detection of telomerase activity in the blood of patients with lung cancer
冯久贤 1包国良 1沙慧芳 1董强刚 1李春海2
作者信息
- 1. 上海市胸科医院上海市胸部肿瘤研究所
- 2. 军事医学科学院
- 折叠
摘要
Abstract
Objective To study the telomerase activity in blood cancer cells by TRAP for monitoring tumor metastasis in blood. Methods Twenty-five patients with lung cancer surgically treated and 35 patients before chemotherapy were determined for telomerase activity of cancer cells in the blood by TRAP, and 30 patients with non-tumor diseases as control. Results In the operative group,13 patients(52％) showed telomerase activity in pulmonary artery blood during operation, which was much higher than that of peripheral blood before operation (24％，P＜0.05). Telomerase positive rate was significantly higher in stage Ⅲ to Ⅳ (64％) than that in stage Ⅰ to Ⅱ (30％,P＜0.05).In the peripheral blood of patients with non-tumor diseases, telomerase was negative. Conclusion Telomerase activity may be an indicator for detecting lung cancer cells in peripheral blood as well as tumor metastasis and relapse.关键词
肺肿瘤/端粒酶/肿瘤标记分类
医药卫生引用本文复制引用
冯久贤,包国良,沙慧芳,董强刚,李春海..肺癌患者血中癌细胞端粒酶活性的检测[J].中国肺癌杂志,2001,4(1):44-46,3.
