南京医科大学学报(英文版)2004，Vol.18Issue(1)：44-47,4.
血清T-PSA和F-PSA检测在乳腺癌诊断中的意义
Measurement of Serum Total and Free Prostate-Specific Antigen for Breast Cancer Diagnosis in Women
张淑群 1杨文彬 1强水云 1李妙羡 1纪宗正1
作者信息
- 1. 西安交通大学第二医院肿瘤外科,西安,710004,中国
- 折叠
摘要
Abstract
Objective: To investigate thediagnostic value and the relationship between the clinicopathological features and the levels of total and free prostate-specific antigen (PSA) in woman with breast cancer. Methods: Using the microparticle enzyme immunoassay system, we measured the concentrations of these markers in the sera of 85 women with breast cancer and in 30 healthy women. Rseults: The lowest detection level for both markers was 0.01 ng/ml. Free PSA levels were significantly higher in women with breast cancer than that in healthy women ( P＜ 0.05). The percentage of free PSA predominant subjects was 37.6% in breast cancer patients and 3.3% in healthy women. Cut-off values were 0.36 ng/ml for total PSA and 0.02 ng/ml for free PSA. In women with breast cancer, total PSA positivity was 23.5% and free PSA positivity was 27.1%. Compared to negatives,total PSA positive patients had a higher percentage of lymph node involvement tumours (P ＞ 0.05). However, patients with predominant free PSA had a higher percentage of early stage than patients with predominant PSA-ACT. Conclusion: Although the sensitivity of free PSA predominance is Iow (37.6%) in distinguishing women with breast cancer from healthy women, its specificity is high (97.0%). Free PSA predominance tends to be present in early stage tumours. lhese findings may indicate clinical significance of preoperative measurement of serum total and free PSA in women with breast cancer.关键词
PSA/诊断/乳腺癌Key words
Prostate-specific antigen/diagnosis/breast cancer分类
医药卫生引用本文复制引用
张淑群,杨文彬,强水云,李妙羡,纪宗正..血清T-PSA和F-PSA检测在乳腺癌诊断中的意义[J].南京医科大学学报(英文版),2004,18(1):44-47,4.
