中山大学学报(自然科学版)2001，Vol.40Issue(1)：44-47,4.
聚乳酸/羟基磷灰石复合材料的研究*Ⅲ.聚(D，L-乳酸)/羟基磷灰石复合材料的体外降解行为
Studies of Polylactide/Hydroxylapatite CompositesⅢ. Thein vitro Degradation Behavior of Poly( D, L-lactide)/Hydroxylapatite Composites
摘要
Abstract
The in vitro degradation behavior of poly ( D, L-lactide) /hydroxylapatite (PDLLA/HA) composite rods with φ 3.2 mm, prepared by oriented compression molding, was tested in physiological saline at 37℃. The changes in relative molecular mass of PDLLA, pH value of the physiological saline and mechanical properties of the composite rods with degradation time were observed. Results showed that HA has significant inhibition on the degradation of PDLLA and thus the composite rods have longer strength-maintaining periods than the pure PDLLA material. SEM observations revealed that bimodal degradation occured in pure PDLLA also appeared in PDLLA/HA composites. The in vitro degradation kinetics of PDLLA in composites was in agreement with the first-order reaction, but the rate constants of degradation were obviously less than that of the pure PDLLA.关键词
聚(D,L-乳酸)/羟基磷灰石/复合材料/体外降解分类
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廖凯荣,赵剑豪,罗丙红,卢泽俭..聚乳酸/羟基磷灰石复合材料的研究*Ⅲ.聚(D，L-乳酸)/羟基磷灰石复合材料的体外降解行为[J].中山大学学报(自然科学版),2001,40(1):44-47,4.
