中华医学杂志（英文版）2002，Vol.115Issue(3)：446-450,5.
Smads蛋白结构与功能的研究进展
Review of current progress in the structure and function of Smad proteins
摘要
Abstract
Purpose To review the recent developments in the structure and function of Smad proteins. Data Sources Both Chinese- and English-language literatures were searched using MEDLINE/CD-ROM (1997-2000) and the Index of Chinese-Language Literature (1997-2000). Study Selection Data from published articles about TGF-β signal transduction in recent domestic and foreign literature were selected. Data Extraction Data were mainly extracted from 22 articles which are listed in the reference section of this review. Results Smad proteins mediate signal transduction induced by the TGF-β superfamily. Based on their structural and functional properties, Smad proteins are divided into three groups. The first group, receptor-regulated Smads (R-Smads), are phosphorylated by activated type Ⅰ receptors and form heteromeric complexes with the second group of Smads, common mediator Smads (Co-Smads). These Smad complexes translocate into the nucleus to influence gene transcription. Inhibitory Smads (I-Smads) are the third group and these antagonize the activity of R-Smads. In the nucleus, Smads can directly contact Smad-binding elements (SBE) in target gene promoters. Through interaction with different transcription factors, transcriptional co-activators or co-repressors, Smads elicit different effects in various cell types. The aberrance of Smad proteins has been noted in several human disorders such as fibrosis, hypertrophic scarring and cancer. Conclusion The structure of Smads determines their function as transcriptional factors which translocate signals from the cell surface to the nucleus where Smads regulate TGF-β superfamily-dependent gene expression.关键词
TGF-β超家族 Smads蛋白 转录因子 信号传导Key words
transformig growth factor-beta/Smad proteins/transcriptional factors/signal transduction分类
医药卫生引用本文复制引用
陈伟,付小兵,盛志勇..Smads蛋白结构与功能的研究进展[J].中华医学杂志（英文版）,2002,115(3):446-450,5.基金项目
This project was supported by a grant from the National Natural Science Foundation of China (No. G1999054204) and the National Prominent Youth Science Foundation of China (No. 39525024). （No. G1999054204）
