首页|期刊导航|中华医学杂志（英文版）|Age-based clinical and angiographic outcomes after sirolimus-eluting stent implantation in patients with coronary artery disease
Age-based clinical and angiographic outcomes after sirolimus-eluting stent implantation in patients with coronary artery disease
XU Bo WU Yong-jian YUAN Jin-qing CHEN Jue YOU Shi-jie DAI Jun XIA Ran GAO Run-lin LI Jian-jun YANG Yue-jin CHEN Ji-lin QIAO Shu-bin QIN Xue-wen MA Wei-hua YAO Min LIU Hai-bo
中华医学杂志（英文版）2007，Vol.120Issue(6)：447-451,5.
中华医学杂志（英文版）2007，Vol.120Issue(6)：447-451,5.
Age-based clinical and angiographic outcomes after sirolimus-eluting stent implantation in patients with coronary artery disease
Age-based clinical and angiographic outcomes after sirolimus-eluting stent implantation in patients with coronary artery disease
摘要
Abstract
Background Advanced age independently predicts early and late mortality and major adverse cardiac events (MACE)after percutaneous coronary intervention (PCI). Randomized clinical trials indicate that sirolimus-eluting stent (SES)implantation reduces target lesion revascularization (TLR), but there are limited data on the impact of age on outcomes following SES implantation in patients with coronary artery disease (CAD) in real-world practice.Methods A total of 333 CAD patients with 453 lesions were enrolled in this study. Subjects were divided into two groups according to age. a young group (＜65 years old, 244 patients with 369 lesions) and elderly group (≥65 years old, 89patients with 113 lesions). Clinical follow-up and quantitative coronary angiography (QCA) were performed seven months after PCI.Results Baseline clinical, demographic, angiographic, and procedural chararcteristics were similar in both groups,except that there were more female patients in the elderly group (21.3% vs 9.8%, P=0.006). Primary success rate was similar in both groups (96.5% in young group vs 95.7% in elderly group, P＞0.05). During angiographic follow-up at 7months, binary in-stent restenosis and in-segment restenosis rates were not significantly different between the two groups (4.7% vs 1.8%; 9.7% vs 8.8%, P＞0.05 respectively). Both sub-acute and late thrombosis rates were similar in the two groups (0.3% vs 0.9% and 1.2% vs 0.9%, P＞0.05 respectively). TLR was not significantly different between the two groups (6.5% vs 3.5%; P=0.246). The rates of bleeding, stroke, angina rehospitalization during the follow-up period were also similar in both groups (P＞0.05 respectively).Conclusion Despite a high-risk clinical profile, coronary SES implantation can be safely and effectively performed in elderly patients with a similar procedural success rate, a low complication rate, and excellent 7-month outcomes.关键词
sirolimus-eluting stent/coronary artery disease/angiography/restenosisKey words
sirolimus-eluting stent/coronary artery disease/angiography/restenosis分类
医药卫生引用本文复制引用
XU Bo,WU Yong-jian,YUAN Jin-qing,CHEN Jue,YOU Shi-jie,DAI Jun,XIA Ran ,GAO Run-lin,LI Jian-jun,YANG Yue-jin,CHEN Ji-lin,QIAO Shu-bin,QIN Xue-wen,MA Wei-hua,YAO Min,LIU Hai-bo..Age-based clinical and angiographic outcomes after sirolimus-eluting stent implantation in patients with coronary artery disease[J].中华医学杂志（英文版）,2007,120(6):447-451,5.基金项目
This study was partly supported by a grant awarded by Dr. LI Jian-jun from Fuwai Hospital, Chinese Academy of Medical Science & Peking Union Medical College, China (No. 2004-190). （No. 2004-190）
