中国病理生理杂志2008，Vol.24Issue(3)：451-455,5.
应用二尖瓣环运动速度和时间指标评价冠心病患者左室整体舒张功能
Mitral annulus velocities and time intervals for evaluation of global left ventricular diastolic function in patients with coronary artery disease
摘要
Abstract
AIM:To detect and compare the longitudinal mitral annulus diastolic velocity and time interval changes by pulsed Doppler tissue imaging(DTI)in patients with angina pectoris(AP)and myocardial infarction(MI),and to explore the value of mitral annulus diastolic velocities and time intervals for evaluation of global left ventricular diastolic dysfunction.METHODS:Fifty patients with established coronary artery disease were divided into AP group(16 cases)and MI group(34 cases).Sixteen age-matched healthy individuals served as the control group.The septum,lateral,anterior and inferior walls of the mitral annulus were displayed,and selected for DTI spectrum sampling.Peak early and late diastolic velocities and their ratio,time to the onset and peak of the early diastolic wave,and regional isovolumic relaxation time were measured,and the average values of the four mitral annular sites were calculated and presented as Em,Am,Em/Am,QEm,TEm and IVRTm,respectively.RESULTS:Compared with the control group,Em and Em/Am were significantly lower in both the AP and the MI groups(P＜0.01).Em was even lower in the MI group than that in the AP group(P＜0.01).QEm,TEm and IVRTm were significantly longer in the AP and the MI groups than those in control group(P＜0.01 or P＜0.05).IVRTm was even longer in the MI group than that in AP group(P＜0.01).IVRTm had significantly negative correlation with Em(r=-0.64,P＜0.01).CONCLUSION:Em,Em/Am,QEm,TEm and IVRTm as measured by pulsed DTI may be promising indexes for quantitative assessment of global left ventricular diastolic dysfunction in patients with coronary artery disease.Em and IVRTm may indicate the severity of ischemic myocardial damage.关键词
多普勒组织成像/超声心动描记术/冠状动脉疾病/左心室舒张功能Key words
Doppler tissue imaging/Echocardiography/Coronary disease/Left ventricular diastolic function分类
医药卫生引用本文复制引用
杨莉,邱琼,张惠忠,伍卫,王景峰..应用二尖瓣环运动速度和时间指标评价冠心病患者左室整体舒张功能[J].中国病理生理杂志,2008,24(3):451-455,5.基金项目
Supported by the Natural Science Foundation of Guangdong Province(No.031706) （No.031706）
