西安医科大学学报2001，Vol.22Issue(1)：45-47,3.
国产利培酮治疗精神分裂症的开放性临床研究
An open trial of domestic risperidone in treating schizophrenia
高成阁 1王芳 2韩德 2亢万虎 1李强 1马现仓 1陈策1
作者信息
- 1. 西安交通大学第一医院精神科,
- 2. 西安市精神卫生中心
- 折叠
摘要
Abstract
Objective The purpose of this study was to observe the safety andefficacy of domestic risperidone in treating of schizophrenia patients in a 6-week open trial.Methods Thirty-three inpatients schizophrenia diagnosed according to Chinese classification and diagnostic criteria of mental disorders, 2 nd edition-revise (CCMD-2-R) took the treatment of risperidon. Its dosage ranged 2～6!mg/day. The positive and negative symptoms scale(PANSS),the brief psychiatric rating scale (BPRS),clinical grobal impressions scale (CGI) were used for the efficacy. Treatment emergent symptom scale(TESS) and Simpson-Angns scales (SAS) were used to assess the unwanted effects.Results At the end of the study,87.9% of the patients were rated as marked improvement and 97% of them as improvement. The clinical effectiveness of risperidone show up at the end of second week of treatment. The optimal dose ranged from 2!mg to 4!mg. The common side effects of risperidone were mild myotonia, tremor,akathisia and drowsiness.Conclusion The domestic risperidone is effective and safe in the treating schizophrenia.关键词
精神分裂症/抗精神病剂/利培酮/临床实验分类
医药卫生引用本文复制引用
高成阁,王芳,韩德,亢万虎,李强,马现仓,陈策..国产利培酮治疗精神分裂症的开放性临床研究[J].西安医科大学学报,2001,22(1):45-47,3.
