摘要
Abstract
Objective To evaluate and compare the ability to detect tumor by bis (N-ethoxy-N-ethyl dithiocarbamato) nitrido 99mTc(V) [ 99mTcN(NOEt) 2 ] and 99mTc hexakis-2- methoxyisobutyl isonitrile [ 99mTc-MIBI ].Methods 99mTcN(NOEt)2 was prepared and quality control was performed using ascending thin-layer chromatography. Four micebearing Ehrich ascites tumor cells underwent whole body planar imaging at 30 min, 2 h and 4 h after injection of 99mTc-MIBI or99m TcN(NOEt) 2@ ROIs were drawn around the tumor, head, chest, and contralateral limbs in whole body planar images, and rati-os of radioactivity in tumor in head (T/H), chest (T/C), and contralateral limbs (T/L) were calculated. The mice of 99mTcN(NOEt) 2 group were killed, then blood was collected, and the tumor and organs were excised, weighed and the radioactivity wasmeasured.Results 99mTcN (NOEt)2 was stable after 4h at the room temperature. 99mTcN (NOEt)2 was delivered to the tumor selectively andefficiently. 99mTcN(NOEt)2 was found to provide excellent tumor-to-nontumor contrast for all the tissue except the abdomen. TheT/L ratios increased to their maximums (4.87) at 2 h after injection. There was significant difference between the 99mTcN(NOEt)2 imaging group and 99mTc-MIBI imaging group. In vitro the radioactivity ratios per unit weight of tumor to blood, muscle,skeleton, lung, heart, and spleen were much higher than those of tumor to liver, instestine.Conclusion In mice bearing Ehrich ascites tumor, 99mTcN(NOEt) 2 exhibits a set of features essential for a good tracer for tumorimaging, including a rapid washout from blood, high uptake rate in tumor tissue, prolonged retention and high tumor-to-nontumoruptake ratio. The imaging quality of 99mTcN (NOEt) 2 was superior to that of 99mTc-MIBI. These features indicate that 99mTcN(NOEt) 2 may be a better tracer to detect tumor than 99mTc-MIBI.关键词
肿瘤/放射性核素显像/NOEt/MIBIKey words
tumor/radionuclide imaging/NOEt/MIBI分类
医药卫生
