中国医学工程2003，Vol.11Issue(6)：45-49,5.
组织自体荧光的Monte Carlo仿真方法
Monte Carlo modeling for tissue autofluorescence
摘要
Abstract
Objective:The excitation light and reemitted fluorescence can be influenced by tissue properties,such as absorption, scattering and other factor. So in order to diagnose tissue with fluorescence, it is important to research into the regulation of fluorescence generating and propagating in theory. Monte Carlo simulation is an efficient method in studying light propagating in human tissue. In this paper, a new photon migration approach for modeling fluorescence in tissue is described in detail based on diffusive reflectance light Monte Carlo model. Methods:In this model, weighted photon model for excitation photon and reemitted fluorescence was utilized. The movement of excitation photon and emitted fluorescence photon is independent of each other. Once a fluorescence packet is generated, it will be traced until termination. And then go on to trace the movement of excitation photon packet. All the statistical values were calculated with modified Monte Carlo Simulation soft ware developed by author. The simulation results of human aortic intima tissue optical model were compared with literature. Results: For human aortic intima model, there are two main fluorescence peaks at emission wavelength 520 nm and 600 nm which is exactly agreed with the results of literature. The relationship between relative fluorescence intensity and escaped radius position indicates that the fluorescence intensity decreases greatly with radius increasing centered on the excitation light source. The result is valuable for the design of exciation and collection fibers in practice. Conclusions:The method presented in this paper is directly induced from the principle of fluorescence generation and movement, and is perspicuous and easily avaiable.For Monte Carlo simulation is based on a large number of random events and statistic regulation,it is time consuming. With the rapid progrss of the computer science and technology, this methodology will play a more important role in the theory and application research of light propagating through complex mediun.关键词
Monte Carlo仿真/自体荧光/光子迁移/组织光学Key words
monte carlo modeling/autofluorescence/photon migration/tissue optics分类
医药卫生引用本文复制引用
夏代林,何继善,张阳德,彭健,刘雁群..组织自体荧光的Monte Carlo仿真方法[J].中国医学工程,2003,11(6):45-49,5.基金项目
Supported by Key Technologies R & D Programme of the tenth five-year plan in China. (No.2001BA706B- 15) （No.2001BA706B- 15）
